Dr. Wruble is a native of Memphis, Tennessee. He attended Jerusalem Torah College in Jerusalem, Israel, before completing his undergraduate studies at Yeshiva University in New York, New York: Dr. Wruble returned to Memphis to attend the University of Tennessee Memphis, The Health Science Center. His internal medicine residency program was completed at the Montefiore Medical Center in Bronx, New York, followed by a GI fellowship at the New York Hospital Medical Center of Queens in Flushing, New York.

Dr. Wruble and his wife, Dena, reside in Memphis with their five children, Justin, Alyssa, Aaron, Sophie, and Emma. He enjoys reading, juggling, playing guitar, basketball and tennis in his spare time.